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"Everyone is going to get to the point where they increase their dosage and it will not work as well as it did before," he says. "The goal is to use the dose that gives the most minimal noticeable effect," says Sulak. "If I see someone with multiple sclerosis who is in the middle of a flare-up and having a really hard time, she may need a higher dose to get the symptoms under control," he says. Sulak has also noticed that the use of lower doses can actually lead to increased sensitivity to cannabis over time, thus underscoring the importance of staying at low levels for the first few days of microdosing. This can be affected by individual differences in liver metabolism, genetics of cannabinoid receptors, and previous usage, to name a few. Each source has a number, and for each entry every line but the first must be indented 5 spaces (a tab) so as to make that first line with the authors name stand out.

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